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KMID : 1024519970060010053
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Journal of the Environmental Sciences
1997 Volume.6 No. 1 p.53 ~ p.60
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Histological and Histochemical Study on Toxicity of Ricin in the Rat Liver
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Jo Un-Bock
Choi Byung-Tae
Jo Gi-Jin
Gil Young-Gi
Kim Jae-Ho
Jang Hye-Young
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Abstract
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The toxicity of purified ricln from Ricinus communis to rats was examined by histological and histochemical methods. Sprague-Dawley rats were injected intraperitoneally with 75/kg body weight of ricin and were sacrified at itntervals of 6, 24, 48 and 120 hours after injectoon. The major morphological changes, such as cloudy swelling, hydropic degeneration, necrosis, fatty change, blood congestion, increase of Kupffer cells in number and extension of sinusoids, were obvious in the liver of experimental group. These morphological changes of hepatic cells were mainly observed in both the periportal and midlobular region of hepatic lobule. The extension of sinusoids was obvious in the controlobular region. And glycogen dlstrlbution of hepatic cells tended to decrease in the same region showing morphlogical changes as compared with the control group.
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KEYWORD
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Ricin, Rat, Liver
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